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過去の講演会
第463回川崎医学会講演会
| :: 日 時 | 令和2年 1月22日（水） 17：00・18：00 |
| :: 場 所 | 本館5階 カンファレンス室 3 |
| :: 座 長 | 石原 克彦 |
「Mechanistic insight on how aging-related inflammation impacts NAD metabolism」
Anthony J. Covarrubias 先生
Decline in tissue NAD levels during aging is linked to aging and its associated diseases. However, the mechanism for aging-associated NAD decline remains unclear. Here we report that pro-inflammatory M1-like macrophages, but not naïve or M2 macrophages, accumulate in metabolic tissues including visceral white adipose tissue and the liver during aging. Remarkably, these M1-like macrophages highly express the NAD consuming enzyme CD38 and have enhanced CD38-dependent NADase activity. We also find that senescent cells progressively accumulate in visceral white adipose tissue during aging and that inflammatory cytokines found in the supernatant from senescent cells (Senescence associated secretory proteins, SASP) induce macrophages to proliferate and to express CD38. These results highlight a new causal link between visceral tissue senescence and tissue NAD decline during aging and represent a novel therapeutic opportunity targeting maintenance of NAD levels during aging.
