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過去の講演会
第567回川崎医学会講演会
| 日 時 | 令和7年7月15日（火）17:00～18:00 |
| 場 所 | 医科大学図書館小講堂 |
| 座 長 | 柏原 直樹 |
| 演 者 | 「Fate of renin cells in health and disease」 Ariel Gomez MD University of Virginia,Harrison Distinguished Prof |
| 演 者 | 「Renin cells, from vascular development to blood pressure sensing」 Maria Luisa MD University of Virginia,Harrison Distinguished Prof |
「Fate of renin cells in health and disease」
We study how renin cells acquire their identity and how changes in their fate result in disease. Renin cells respond to changes in perfusion pressure and the volume and composition of the extracellular fluid. Normally, a few JG cells secrete renin and maintain homeostasis, but if there is a homeostatic threat, smooth muscle cells along the kidney arterioles have the plasticity to synthesize and release renin. This ability so important to sustain well-being may lead to pathology if homeostasis is not regained resulting in concentric arteriolar hypertrophy and decreased glomerular filtration. Given that 1.3 billion people are hypertensive and are frequently treated with renin-angiotensin inhibitors, it is urgent to uncover mechanism and develop strategies to preserve kidney health while preventing the deleterious effects of hypertension.
「Renin cells, from vascular development to blood pressure sensing」
In the embryo, renin cells are widely distributed throughout the renal vasculature and contribute to the development of the renal arterial tree. With maturation, they differentiate into other cell types and become confined to the tips of the arterioles, thus their name juxtaglomerular cells. Juxtaglomerular cells are sensors that release renin to control blood pressure and fluid-electrolyte homeostasis. Three major mechanisms control renin release: β-adrenergic stimulation, macula densasignaling, and the baroreceptor, whereby a decrease in arterial pressure leads to increased renin release and viceversa. The renin cell baroreceptor transmits external forces via integrin β1 to the chromatin to regulate Ren1expression. We will discuss the origins of renin cells, their role in kidney vascular development and current understanding of the blood pressure sensing mechanism.
詳細はこちら
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